Cellular lipid catabolic process

pathway activity — cross-omics
GO:0044242Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cellular lipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAOA, MCMBP, and MKI67_S357, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADMAOA →+0.518+0.013<.001<.00137
PDACMCMBP →-0.311-0.035<.001<.00137
LUADMKI67_S357 →-1.128-0.031.005<.00137
LUADPBLD →+0.509+0.017<.001.00737
GBMSMCHD1 →-0.339-0.036<.001<.00137
GBMFYCO1 →+0.336+0.034<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration