Cellular lipid catabolic process

pathway activity — cross-omics
GO:0044242Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cellular lipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAF15, NUP50, and PRPF40A_S861, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADTAF15 →-0.295-0.167<.001<.00134
UCECNUP50 →-0.252-0.202.004.00134
OVPRPF40A_S861 →-1.370-0.236<.001<.00134
COADSERBP1 →-0.198-0.196.001.00133
CCRCCSS18 →-0.248-0.323<.001<.00133
BRCATAF12 →-0.222-0.211<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration