Lipid digestion

Across TCGA patient cohorts, RNA activity of the Lipid digestion pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COBLL1, CYGB, and LPCAT3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid digestion activity versus COBLL1 in PDAC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	COBLL1 →	+0.167	+0.125	.001	<.001	3	6
OV	CYGB →	+0.848	+0.056	<.001	.002	3	5
UCEC	LPCAT3 →	+0.383	+0.069	.007	.001	3	5
PDAC	MLYCD →	+0.153	+0.136	.002	<.001	3	5
PDAC	PFDN6 →	-0.201	-0.130	<.001	<.001	3	5
PDAC	ARL3 →	-0.320	-0.154	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044241 vs COBLL1 — PDAC

Explore this scatter interactively →