Lipid digestion

Across TCGA patient cohorts, RNA activity of the Lipid digestion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMA1, EHMT2, and ANXA5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid digestion activity versus LIMA1 in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LIMA1 →	+1.081	+0.566	<.001	<.001	3	8
COAD	EHMT2 →	-0.436	-0.125	.002	.006	3	6
OV	ANXA5 →	+0.816	+0.215	<.001	<.001	3	6
OV	SMIM3 →	+0.886	+0.224	<.001	<.001	3	6
LSCC	E2F1 →	-0.781	-0.231	.001	.001	3	6
LSCC	RNASEH2A →	-0.166	-0.165	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044241 vs LIMA1 — HNSC

Explore this scatter interactively →