Lipid digestion

Across TCGA cell cohorts, RNA activity of the Lipid digestion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA20, MACC1, and HDAC9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPATA20 grouped by Lipid digestion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPATA20 →	-1.575	-0.989	.001	.001	3	4
LUNG_NSCLC_LUSC	MACC1 →	+2.664	+1.071	.001	.004	3	4
LUNG_NSCLC_LUSC	HDAC9 →	+2.108	+1.032	.001	.006	3	4
STOMACH	NABP1 →	-1.913	-1.255	.001	.002	3	4
SKIN	NUDT6 →	-0.545	-0.744	.005	.006	3	3
SKIN	EPHB4 →	-0.707	-0.696	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPATA20 by Lipid digestion activity — LUNG_SCLC

Explore this box plot interactively →