Lipid digestion

Across TCGA cell cohorts, RNA activity of the Lipid digestion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMA1, MET, and PHLDB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid digestion activity versus LIMA1 in BLOOD_Lymphoma (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LIMA1 →	+2.991	+1.727	.001	.001	3	6
LARGE_INTESTINE	MET →	+0.895	+0.316	.001	.008	3	5
LARGE_INTESTINE	PHLDB2 →	+3.572	+0.571	<.001	.009	3	4
LIVER	RGPD8 →	+0.840	+0.275	.002	.004	3	4
URINARY_TRACT	POLR2D →	-0.537	-0.251	.001	.004	3	3
URINARY_TRACT	PRKX →	-1.910	-0.239	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044241 vs LIMA1 — BLOOD_Lymphoma

Explore this scatter interactively →