AMP salvage

Across TCGA patient cohorts, RNA activity of the AMP salvage pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADA, NGDN_S143, and BBS7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMP salvage activity versus ADA in GBM (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADA →	+0.697	+0.058	<.001	<.001	3	8
UCEC	NGDN_S143 →	+0.538	+0.047	<.001	.008	3	8
GBM	BBS7 →	-0.364	-0.050	<.001	<.001	3	6
BRCA	DDX21 →	+0.535	+0.060	<.001	<.001	3	6
BRCA	DDAH1 →	-0.702	-0.056	<.001	<.001	3	6
OV	IFT122 →	-0.337	-0.061	.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044209 vs ADA — GBM

Explore this scatter interactively →