AMP salvage

Across TCGA cell cohorts, RNA activity of the AMP salvage pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATR, NEPRO, and S100A14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATR grouped by AMP salvage-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ATR →	-0.561	-1.236	<.001	<.001	3	4
LUNG_NSCLC_LUAD	NEPRO →	-0.571	-0.774	.006	.001	3	4
LUNG_NSCLC_LUAD	S100A14 →	+3.374	+0.775	.003	.001	3	4
OVARY	FXYD3 →	+3.100	+0.914	.002	.007	3	4
BLOOD_Myeloma	BPNT2 →	+0.777	+0.377	.007	.005	3	4
STOMACH	MAP7 →	+2.501	+0.804	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATR by AMP salvage activity — SOFT_TISSUE

Explore this box plot interactively →