'de novo' AMP biosynthetic process

Across TCGA cell cohorts, RNA activity of the 'de novo' AMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCF7L1, FAM174B, and RAB3IL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCF7L1 grouped by 'de novo' AMP biosynthetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TCF7L1 →	-1.193	-0.714	.002	.002	3	5
OESOPHAGUS	FAM174B →	+2.151	+0.537	.001	.002	3	4
STOMACH	RAB3IL1 →	-1.741	-0.669	.001	.006	3	4
STOMACH	MSRB3 →	-2.331	-0.709	<.001	.003	3	4
BREAST	MAPK13 →	+1.364	+0.377	.009	.008	3	4
LUNG_NSCLC_LUAD	GJC1 →	-1.893	-0.423	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCF7L1 by 'de novo' AMP biosynthetic process activity — OVARY

Explore this box plot interactively →