'de novo' AMP biosynthetic process

Across TCGA cell cohorts, RNA activity of the 'de novo' AMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFAS, PPAT, and PAICS, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 'de novo' AMP biosynthetic process activity versus PFAS in BREAST (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PFAS →	+1.365	+0.135	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	PPAT →	+1.220	+0.193	<.001	.001	3	20
UPPER_AERODIGESTIVE_TRACT	PAICS →	+1.410	+0.165	<.001	.003	3	19
BLOOD_Lymphoma	TSR1 →	+1.067	+0.137	<.001	<.001	3	18
BREAST	GEMIN4 →	+1.200	+0.148	<.001	<.001	3	18
OESOPHAGUS	DHX33 →	+1.147	+0.184	.004	.006	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044208 vs PFAS — BREAST

Explore this scatter interactively →