'de novo' AMP biosynthetic process

Across TCGA cell cohorts, RNA activity of the 'de novo' AMP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL4, RPLP0, and SSBP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 'de novo' AMP biosynthetic process activity versus RPL4 in OVARY (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RPL4 →	+0.991	+1.524	.001	.001	3	8
OVARY	RPLP0 →	+0.770	+1.421	.005	.002	3	8
LARGE_INTESTINE	SSBP4 →	+0.994	+0.385	.002	<.001	3	7
BLOOD_Myeloma	C1QBP →	+1.580	+0.261	.004	.003	3	7
BLOOD_Lymphoma	PAICS →	+0.713	+0.197	.005	.004	3	7
LUNG_SCLC	GPD1L →	+1.518	+0.449	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044208 vs RPL4 — OVARY

Explore this scatter interactively →