Membrane biogenesis

Across TCGA patient cohorts, RNA activity of the Membrane biogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSME2, MAN2A1, and GMPPB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane biogenesis activity versus PSME2 in LUAD (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PSME2 →	-0.536	-0.032	<.001	<.001	3	5
HNSC	MAN2A1 →	-0.296	-0.047	<.001	.002	3	5
LUAD	GMPPB →	-0.147	-0.027	.009	.003	3	5
GBM	SEC61B →	-0.533	-0.042	<.001	.002	3	4
COAD	BCL2L12_S242 →	-0.252	-0.018	.004	.001	3	4
BRCA	MID1 →	+0.449	+0.023	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044091 vs PSME2 — LUAD

Explore this scatter interactively →