Membrane biogenesis

Across TCGA patient cohorts, RNA activity of the Membrane biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF385C, FANCI, and TICRR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane biogenesis activity versus ZNF385C in CCRCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZNF385C →	+0.320	+0.120	<.001	.008	3	4
UCEC	FANCI →	-0.675	-0.160	<.001	.002	3	4
UCEC	TICRR →	-0.815	-0.194	<.001	<.001	3	4
UCEC	EME1 →	-0.942	-0.211	<.001	<.001	3	4
BRCA	PDCD5 →	-0.789	-0.196	<.001	<.001	3	4
BRCA	ANK3 →	+0.904	+0.189	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044091 vs ZNF385C — CCRCC

Explore this scatter interactively →