Membrane biogenesis

Across TCGA patient cohorts, RNA activity of the Membrane biogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIZ_S1344, DDX18, and TRPS1_S90, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane biogenesis activity versus WIZ_S1344 in LSCC (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WIZ_S1344 →	-0.532	-0.177	<.001	<.001	3	4
BRCA	DDX18 →	-0.294	-0.108	<.001	.001	3	4
BRCA	TRPS1_S90 →	-1.036	-0.177	<.001	<.001	3	4
OV	PPP1R12A_S422 →	-0.909	-0.170	<.001	<.001	3	4
OV	TP53_S315 →	-1.503	-0.225	<.001	<.001	3	3
CCRCC	RAD54L2 →	-0.332	-0.153	.003	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044091 vs WIZ_S1344 — LSCC

Explore this scatter interactively →