Membrane biogenesis

Across TCGA cell cohorts, RNA activity of the Membrane biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR77, AGO2, and NAPSA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR77 grouped by Membrane biogenesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	WDR77 →	-0.927	-0.305	.001	<.001	3	5
LUNG_SCLC	AGO2 →	+0.730	+0.211	<.001	.001	3	5
BONE	NAPSA →	+0.478	+0.192	<.001	<.001	3	5
CNS	KIAA1958 →	+0.801	+0.461	.008	.004	3	4
BLOOD_Leukemia	TONSL →	+0.514	+0.509	.002	.006	3	4
LUNG_NSCLC_LUAD	FXN →	-0.474	-0.188	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR77 by Membrane biogenesis activity — PANCREAS

Explore this box plot interactively →