Membrane biogenesis

Across TCGA cell cohorts, RNA activity of the Membrane biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMM1, STN1, and PRDM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane biogenesis activity versus PMM1 in OVARY (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PMM1 →	+1.003	+0.253	.001	.002	3	5
OESOPHAGUS	STN1 →	+0.948	+0.167	.007	.009	3	4
LARGE_INTESTINE	PRDM1 →	-1.156	-0.191	<.001	<.001	3	4
BLOOD_Leukemia	FAM111B →	+2.046	+0.201	.001	.005	3	4
BLOOD_Leukemia	NANOGP8 →	-0.052	-0.155	.004	.003	3	4
BLOOD_Leukemia	H2AC8 →	+0.873	+0.160	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044091 vs PMM1 — OVARY

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