Positive regulation of vacuole organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of vacuole organization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HES6, CSF1, and ZNF764, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HES6 grouped by Positive regulation of vacuole organization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HES6 →	+1.252	+1.004	.007	.001	3	5
LUNG_SCLC	CSF1 →	-1.465	-0.977	.002	.003	3	5
LUNG_SCLC	ZNF764 →	+1.018	+1.486	<.001	<.001	3	4
LUNG_NSCLC_LUSC	SNX21 →	-1.571	-1.445	.002	<.001	3	4
LUNG_SCLC	AJUBA →	-2.486	-1.338	.003	.001	3	4
LUNG_NSCLC_LUSC	TSPAN2 →	-1.188	-1.443	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HES6 by Positive regulation of vacuole organization activity — LARGE_INTESTINE

Explore this box plot interactively →