Positive regulation of vacuole organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of vacuole organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, CXXC1, and ACTN4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vacuole organization activity versus ANXA2 in LUNG_SCLC (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANXA2 →	+4.118	+1.622	<.001	<.001	3	7
BLOOD_Leukemia	CXXC1 →	-0.583	-0.848	.003	.006	3	6
BLOOD_Lymphoma	ACTN4 →	+1.239	+1.191	<.001	<.001	3	5
BLOOD_Lymphoma	SYTL3 →	+2.698	+1.311	<.001	<.001	3	5
BLOOD_Leukemia	SOBP →	-0.757	-0.735	.003	.002	3	5
BLOOD_Leukemia	TMBIM1 →	+2.071	+1.017	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044090 vs ANXA2 — LUNG_SCLC

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