Regulation of vacuole organization

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of vacuole organization pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 57 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Regulation of vacuole organization pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and HNSC, show the opposite pattern, with higher activity associated with better survival.

SCLC, HNSC, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	II,III,IV	0.650	0.169	<.001	77	view →
HNSC	DFS	Median	IV	0.646	0.467	<.001	61	view →
UVM	DFS	Quartile	III,IV	0.187	0.848	<.001	55	view →
SKCM	DFS	Quartile	All	0.724	0.580	.003	54	view →
LGG	DFS	Median	All	0.598	0.822	<.001	53	view →
BRCA	DFS	Median	III,IV	0.626	0.417	<.001	37	view →
READ	OS	Quartile	II,III,IV	1.000	0.368	.002	21	view →
UCS	DFS	Tertile	II,III,IV	0.612	0.200	.011	20	view →
BLCA	DFS	Tertile	All	0.212	0.561	.019	19	view →
LUAD	DFS	Tertile	IV	0.416	0.817	.014	18	view →
CESC	DFS	Tertile	All	0.448	0.676	.015	16	view →
ESCA	OS	Tertile	III,IV	0.675	0.310	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0044088–SCLC (OS)

Open the SCLC breakdown →