Regulation of digestive system process

Across TCGA patient cohorts, RNA activity of the Regulation of digestive system process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDAC2, AGFG2, and KPNA2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of digestive system process activity versus HDAC2 in BRCA (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HDAC2 →	-0.352	-0.054	<.001	<.001	3	7
PDAC	AGFG2 →	+0.408	+0.056	<.001	<.001	3	6
BRCA	KPNA2 →	-0.955	-0.065	<.001	<.001	3	6
GBM	RBM47 →	+0.467	+0.055	<.001	.001	3	6
PDAC	NECAP1 →	+0.275	+0.048	<.001	.002	3	6
GBM	NUDT1 →	-0.432	-0.069	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044058 vs HDAC2 — BRCA

Explore this scatter interactively →