Regulation of digestive system process

Across TCGA patient cohorts, RNA activity of the Regulation of digestive system process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF7-AS1, SYNE3, and FBXO5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of digestive system process activity versus ARHGEF7-AS1 in HNSC (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGEF7-AS1 →	-0.618	-0.356	.001	.004	3	4
PDAC	SYNE3 →	+0.333	+0.166	.002	.005	3	4
COAD	FBXO5 →	-0.350	-0.142	.001	<.001	3	4
COAD	SRSF3 →	-0.404	-0.194	.001	.002	3	4
BRCA	GCOM1 →	+0.457	+0.216	.002	.003	3	4
BRCA	GCSAM →	+0.832	+0.234	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044058 vs ARHGEF7-AS1 — HNSC

Explore this scatter interactively →