Regulation of digestive system process

Across TCGA cell cohorts, RNA activity of the Regulation of digestive system process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERF1A, PBX4, and RPL9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERF1A grouped by Regulation of digestive system process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SERF1A →	-0.963	-1.215	.002	.002	3	5
LIVER	PBX4 →	-1.308	-1.644	.002	<.001	3	5
OESOPHAGUS	RPL9 →	+0.695	+0.853	.004	<.001	3	5
LIVER	PC →	+1.909	+1.704	.006	<.001	3	4
KIDNEY	HENMT1 →	-1.450	-1.072	.004	.003	3	4
SOFT_TISSUE	NREP →	+3.708	+1.042	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERF1A by Regulation of digestive system process activity — BONE

Explore this box plot interactively →