Regulation of digestive system process

Across TCGA cell cohorts, RNA activity of the Regulation of digestive system process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB32, EPB41, and IKBIP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of digestive system process activity versus RAB32 in BREAST (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAB32 →	-2.416	-1.098	.001	.001	2	6
BONE	EPB41 →	+3.700	+1.706	.004	<.001	3	4
BLOOD_Lymphoma	IKBIP →	-0.817	-1.061	<.001	.002	3	4
LUNG_NSCLC_LUAD	SLC43A3 →	+2.169	+0.582	.003	.002	3	4
LARGE_INTESTINE	PPP3CA →	+1.164	+0.903	.001	.001	3	4
LUNG_SCLC	NAP1L2 →	-1.230	-1.203	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044058 vs RAB32 — BREAST

Explore this scatter interactively →