Glucan metabolic process

Across TCGA patient cohorts, RNA activity of the Glucan metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1_S351, BBS7, and EVI2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucan metabolic process activity versus RCSD1_S351 in LUAD (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RCSD1_S351 →	-0.526	-0.039	<.001	<.001	3	7
BRCA	BBS7 →	+0.375	+0.046	<.001	<.001	3	6
BRCA	EVI2B →	-0.540	-0.026	<.001	<.001	3	6
BRCA	FAM172A →	+0.322	+0.036	<.001	<.001	3	6
BRCA	GMIP →	-0.267	-0.040	<.001	<.001	3	6
BRCA	IKZF1_S63 →	-1.041	-0.041	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044042 vs RCSD1_S351 — LUAD

Explore this scatter interactively →