Glucan metabolic process

Across TCGA patient cohorts, RNA activity of the Glucan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA2, ZWINT, and CNN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucan metabolic process activity versus LAMA2 in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LAMA2 →	+0.953	+0.185	<.001	.004	3	6
LUAD	ZWINT →	-0.799	-0.143	<.001	.007	3	6
UCEC	CNN1 →	+1.864	+0.207	<.001	<.001	3	6
UCEC	LMOD1 →	+1.397	+0.184	<.001	<.001	3	6
BRCA	HSPB7 →	+1.112	+0.192	<.001	<.001	3	6
BRCA	EXO1 →	-0.944	-0.211	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044042 vs LAMA2 — BRCA

Explore this scatter interactively →