Glucan metabolic process

Across TCGA cell cohorts, RNA activity of the Glucan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACO1, MED20, and FCN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACO1 grouped by Glucan metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ACO1 →	-1.826	-0.915	<.001	.009	3	4
BLOOD_Leukemia	MED20 →	+0.636	+1.120	.003	<.001	3	4
PANCREAS	FCN3 →	+0.095	+1.037	<.001	<.001	3	3
PANCREAS	TRIM36 →	-1.221	-1.038	.008	.002	3	3
LUNG_NSCLC_LUSC	NOL4L →	+1.717	+0.950	<.001	.006	3	3
OVARY	EBI3 →	+1.572	+1.003	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACO1 by Glucan metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →