Glucan metabolic process

Across TCGA cell cohorts, RNA activity of the Glucan metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDN1, UBR5, and TRAF3IP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucan metabolic process activity versus EDN1 in LARGE_INTESTINE (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EDN1 →	-2.279	-1.169	<.001	<.001	3	4
PANCREAS	UBR5 →	+0.515	+0.790	.001	.004	3	4
PANCREAS	TRAF3IP1 →	+0.867	+0.944	<.001	.002	3	4
BLOOD_Lymphoma	RRAGD →	+2.130	+0.194	.001	.009	3	4
UPPER_AERODIGESTIVE_TRACT	RPGRIP1L →	+0.762	+1.374	.009	.001	3	3
BLOOD_Myeloma	ZNF330 →	+0.779	+0.189	.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044042 vs EDN1 — LARGE_INTESTINE

Explore this scatter interactively →