Negative regulation of gene expression via chromosomal CpG island methylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of gene expression via chromosomal CpG island methylation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18A, DDIAS, and ORC6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of gene expression via chromosomal CpG island methylation activity versus KIF18A in LSCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KIF18A →	+0.579	+0.281	<.001	.009	3	5
LSCC	DDIAS →	+0.532	+0.384	<.001	<.001	3	5
LSCC	ORC6 →	+0.767	+0.555	<.001	<.001	3	5
LSCC	NCAPD2 →	+0.641	+0.499	.001	.003	3	4
LSCC	FCGRT →	-0.272	-0.327	.005	.002	3	4
LSCC	FOXM1 →	+0.735	+0.570	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044027 vs KIF18A — LSCC

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