Negative regulation of gene expression via chromosomal CpG island methylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of gene expression via chromosomal CpG island methylation pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UHRF1, DNMT1, and MTA2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of gene expression via chromosomal CpG island methylation activity versus UHRF1 in BLOOD_Lymphoma (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	UHRF1 →	+1.574	+0.523	<.001	.002	3	12
SOFT_TISSUE	DNMT1 →	+1.005	+0.774	<.001	.003	3	12
UPPER_AERODIGESTIVE_TRACT	MTA2 →	+0.837	+1.213	.005	.001	3	10
SOFT_TISSUE	BUB3 →	+0.623	+0.783	<.001	.003	3	10
LARGE_INTESTINE	RANGAP1 →	+0.490	+0.939	.005	.004	3	9
LARGE_INTESTINE	EXOSC4 →	+0.515	+0.780	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044027 vs UHRF1 — BLOOD_Lymphoma

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