Cellular component maintenance

Across TCGA patient cohorts, RNA activity of the Cellular component maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAI14, FSTL1, and S100A11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular component maintenance activity versus RAI14 in COAD (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RAI14 →	+0.292	+0.023	.002	<.001	3	5
OV	FSTL1 →	+0.702	+0.043	.001	.004	3	5
LSCC	S100A11 →	+0.433	+0.035	.003	.002	3	5
GBM	FANCD2_S1435 →	-0.477	-0.025	.006	.008	3	4
OV	RIPOR1 →	+0.402	+0.050	<.001	<.001	3	4
BRCA	TIMP2 →	+0.602	+0.034	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043954 vs RAI14 — COAD

Explore this scatter interactively →