Cellular component maintenance

Across TCGA patient cohorts, RNA activity of the Cellular component maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLAMF1, C1orf210, and STAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular component maintenance activity versus SLAMF1 in BRCA (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLAMF1 →	-0.763	-0.637	.002	.001	3	5
CCRCC	C1orf210 →	+0.975	+0.520	.007	<.001	3	5
HNSC	STAP1 →	-0.739	-0.561	<.001	<.001	3	5
LUAD	TNFRSF13B →	-0.396	-0.483	<.001	.002	3	5
HNSC	SLA2 →	-0.878	-0.488	<.001	<.001	3	4
HNSC	PPP1R16B →	-0.911	-0.498	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043954 vs SLAMF1 — BRCA

Explore this scatter interactively →