Cellular component maintenance

Across TCGA cell cohorts, RNA activity of the Cellular component maintenance pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNAP29, DDX10, and SMTN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNAP29 grouped by Cellular component maintenance-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SNAP29 →	-0.571	-1.186	.008	.001	3	4
LUNG_NSCLC_LUAD	DDX10 →	+1.023	+0.844	<.001	.001	3	3
LUNG_NSCLC_LUAD	SMTN →	-0.668	-0.590	.004	.001	3	3
LUNG_NSCLC_LUAD	PI4KA →	-0.565	-0.537	.006	.003	3	3
BREAST	MID2 →	-1.212	-0.464	.001	.007	3	3
SOFT_TISSUE	GPR68 →	-1.281	-1.449	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNAP29 by Cellular component maintenance activity — SOFT_TISSUE

Explore this box plot interactively →