Positive regulation of cAMP-mediated signaling

pathway activity — cross-omics
GO:0043950Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of cAMP-mediated signaling pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C17orf97, MICALL1_S621, and NCL_T76, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECC17orf97 →+0.453+0.057.001.00834
COADMICALL1_S621 →-0.399-0.039<.001<.00134
LUADNCL_T76 →-1.062-0.043.002<.00134
BRCARRAS2 →+0.487+0.035.009.00433
COADSIRT1_S47 →+0.202+0.029.008<.00133
CCRCCRANBP2_S2900 →+0.460+0.031.004.00233
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration