Negative regulation by host of viral transcription

Across TCGA cell cohorts, RNA activity of the Negative regulation by host of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST7L, RAB11B, and HOXB5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST7L grouped by Negative regulation by host of viral transcription-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ST7L →	+1.032	+0.333	.008	.003	3	4
BREAST	RAB11B →	-0.703	-0.188	<.001	.003	3	4
SOFT_TISSUE	HOXB5 →	+1.888	+0.237	.002	.006	3	3
CNS	NYNRIN →	+1.204	+0.277	.004	.001	3	3
LUNG_SCLC	DDX58 →	-1.239	-0.356	.001	<.001	3	3
LUNG_NSCLC_LUAD	AKAP3 →	-0.509	-0.186	<.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST7L by Negative regulation by host of viral transcription activity — BLOOD_Myeloma

Explore this box plot interactively →