Negative regulation by host of viral transcription

Across TCGA cell cohorts, RNA activity of the Negative regulation by host of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPC2, PLP2, and VANGL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation by host of viral transcription activity versus GPC2 in BLOOD_Leukemia (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPC2 →	+1.084	+0.116	.009	.009	3	7
OVARY	PLP2 →	-2.027	-0.327	<.001	.001	1	7
OVARY	VANGL2 →	+1.785	+0.319	.001	<.001	3	5
BLOOD_Lymphoma	SLC22A4 →	-1.636	-0.335	<.001	.009	3	5
STOMACH	BCL9 →	+2.226	+0.548	.002	<.001	3	5
STOMACH	ZBTB12 →	+1.143	+0.608	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043922 vs GPC2 — BLOOD_Leukemia

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