Regulation of biological process involved in symbiotic interaction

Across TCGA cell cohorts, RNA activity of the Regulation of biological process involved in symbiotic interaction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, FHL3, and CD276, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of biological process involved in symbiotic interaction activity versus LGALS1 in BREAST (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LGALS1 →	+4.530	+0.355	<.001	<.001	3	8
BLOOD_Lymphoma	FHL3 →	+1.924	+0.289	<.001	<.001	3	8
BLOOD_Leukemia	CD276 →	+1.220	+0.142	.005	.004	3	7
BLOOD_Lymphoma	SERPINH1 →	+2.866	+0.380	<.001	<.001	3	7
LUNG_NSCLC_LUAD	TGFB1 →	+1.995	+0.242	<.001	.002	3	7
BLOOD_Lymphoma	OPTN →	+3.150	+0.314	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043903 vs LGALS1 — BREAST

Explore this scatter interactively →