Dedifferentiation

Across TCGA cell cohorts, RNA activity of the Dedifferentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNTA1, ELOF1, and SKI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNTA1 grouped by Dedifferentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SNTA1 →	-0.880	-1.035	.002	.001	3	5
STOMACH	ELOF1 →	-1.053	-1.647	.001	<.001	3	4
OVARY	SKI →	-0.600	-0.940	.008	.007	3	4
OVARY	SLC2A4 →	-0.403	-0.871	.008	.002	3	4
SKIN	ZNF664 →	+0.437	+0.872	.006	.008	3	4
PANCREAS	SNAPC4 →	-0.821	-1.170	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNTA1 by Dedifferentiation activity — CNS

Explore this box plot interactively →