Dedifferentiation

Across TCGA cell cohorts, RNA activity of the Dedifferentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNDC7, EDNRA, and PRMT3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FNDC7 grouped by Dedifferentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FNDC7 →	+0.509	+0.169	<.001	.003	3	2
BREAST	EDNRA →	+0.116	+0.169	.006	.003	3	2
PANCREAS	PRMT3 →	+0.197	+0.202	.001	.002	3	2
KIDNEY	NPR2 →	+0.178	+0.157	.002	.003	3	2
KIDNEY	AP3M1 →	-0.453	-0.215	.001	.005	3	2
KIDNEY	LHX1 →	+0.242	+0.157	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FNDC7 by Dedifferentiation activity — BREAST

Explore this box plot interactively →