Dedifferentiation

Across TCGA cell cohorts, RNA activity of the Dedifferentiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRR, UBAP2, and ZNF77, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dedifferentiation activity versus PTPRR in KIDNEY (Pearson r = -0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PTPRR →	-2.292	-0.172	<.001	.006	3	3
BLOOD_Leukemia	UBAP2 →	+0.710	+0.189	.005	.005	3	3
BLOOD_Lymphoma	ZNF77 →	-1.793	-0.099	.003	.002	3	3
PANCREAS	PSMD4 →	+0.639	+0.122	.001	.009	3	2
PANCREAS	PPP1R21 →	+0.825	+0.164	<.001	.006	3	2
PANCREAS	CLK2 →	+0.937	+0.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043696 vs PTPRR — KIDNEY

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