Mitochondrial fragmentation involved in apoptotic process

Across TCGA patient cohorts, RNA activity of the Mitochondrial fragmentation involved in apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS9-AS2, RECK, and PDLIM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial fragmentation involved in apoptotic process activity versus ADAMTS9-AS2 in UCEC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADAMTS9-AS2 →	-0.734	-0.138	.007	.007	3	5
UCEC	RECK →	-0.578	-0.169	.007	.001	3	4
BRCA	PDLIM4 →	-0.946	-0.117	.003	<.001	3	4
BRCA	MRAS →	-0.789	-0.104	<.001	.002	3	4
BRCA	LINC02202 →	-0.278	-0.105	.001	.001	3	4
CCRCC	FAM110D →	-0.605	-0.165	.002	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043653 vs ADAMTS9-AS2 — UCEC

Explore this scatter interactively →