Mitochondrial fragmentation involved in apoptotic process

Across TCGA cell cohorts, RNA activity of the Mitochondrial fragmentation involved in apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HERC6, NPAS1, and NOMO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HERC6 grouped by Mitochondrial fragmentation involved in apoptotic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HERC6 →	-0.895	-0.365	<.001	<.001	3	4
URINARY_TRACT	NPAS1 →	+0.938	+0.322	.001	.001	3	4
BLOOD_Myeloma	NOMO1 →	-0.827	-0.369	<.001	<.001	3	3
SKIN	DDX58 →	-1.139	-0.343	<.001	.001	3	3
BLOOD_Myeloma	PLAC8 →	-2.969	-0.369	.001	<.001	3	3
BONE	NOMO2 →	-1.310	-0.322	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HERC6 by Mitochondrial fragmentation involved in apoptotic process activity — SKIN

Explore this box plot interactively →