Mitochondrial fragmentation involved in apoptotic process

Across TCGA cell cohorts, RNA activity of the Mitochondrial fragmentation involved in apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BNIP3L, BNIP3, and P4HA1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial fragmentation involved in apoptotic process activity versus BNIP3L in LIVER (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	BNIP3L →	+1.953	+0.196	<.001	.001	3	18
OVARY	BNIP3 →	+1.866	+0.193	<.001	<.001	3	13
OVARY	P4HA1 →	+1.548	+0.177	<.001	<.001	3	12
SOFT_TISSUE	GPR176 →	+1.671	+0.114	<.001	<.001	3	12
BONE	LOXL2 →	+3.870	+0.193	<.001	<.001	3	11
BONE	DRAP1 →	+1.452	+0.258	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043653 vs BNIP3L — LIVER

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