Mitochondrial fragmentation involved in apoptotic process

Across TCGA cell cohorts, RNA activity of the Mitochondrial fragmentation involved in apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLPBP, CPA4, and ZNF101, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial fragmentation involved in apoptotic process activity versus PLPBP in OVARY (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PLPBP →	+0.928	+0.326	.004	<.001	2	7
BONE	CPA4 →	-4.680	-0.392	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ZNF101 →	+0.979	+0.325	<.001	.001	3	5
STOMACH	NDUFA5 →	+1.007	+0.350	.005	.001	3	5
LIVER	YARS2 →	+0.675	+0.293	.005	.008	3	5
PANCREAS	MRPL4 →	+0.969	+0.379	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043653 vs PLPBP — OVARY

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