Engulfment of apoptotic cell

Across TCGA patient cohorts, RNA activity of the Engulfment of apoptotic cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP15_S1012, LIMK2_S293, and SDS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Engulfment of apoptotic cell activity versus FKBP15_S1012 in GBM (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FKBP15_S1012 →	+0.378	+0.052	.003	.001	3	4
GBM	LIMK2_S293 →	+0.271	+0.035	.009	.008	3	4
UCEC	SDS →	+0.563	+0.075	.001	.003	2	5
BRCA	FOXA1_S331 →	+0.744	+0.042	.008	.002	2	5
CCRCC	PEX6 →	+0.157	+0.027	.003	.002	3	4
LUAD	TCF4_S372 →	-0.378	-0.046	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043652 vs FKBP15_S1012 — GBM

Explore this scatter interactively →