Engulfment of apoptotic cell

Across TCGA patient cohorts, RNA activity of the Engulfment of apoptotic cell pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALOX15, PLEKHG7, and SCN9A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Engulfment of apoptotic cell activity versus ALOX15 in HNSC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ALOX15 →	+1.434	+0.207	<.001	<.001	3	4
HNSC	PLEKHG7 →	+0.861	+0.153	.005	.003	3	4
LUAD	SCN9A →	-0.650	-0.107	.001	.008	3	4
COAD	CLC →	+1.761	+0.310	<.001	.006	3	4
HNSC	ADH1C →	+1.135	+0.121	<.001	<.001	3	4
COAD	IL1RL1 →	+0.531	+0.293	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043652 vs ALOX15 — HNSC

Explore this scatter interactively →