Linoleic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Linoleic acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MVD, FADS2, and HMGCS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Linoleic acid metabolic process activity versus MVD in BRCA (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MVD →	+0.385	+0.037	<.001	<.001	3	6
BRCA	FADS2 →	+0.937	+0.068	<.001	<.001	3	6
BRCA	HMGCS1 →	+0.514	+0.052	.005	.001	3	6
UCEC	IRS2_S731 →	-0.853	-0.098	<.001	.001	3	5
HNSC	SQLE →	+0.608	+0.092	<.001	<.001	3	5
BRCA	NUDT8 →	+0.506	+0.057	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043651 vs MVD — BRCA

Explore this scatter interactively →