Linoleic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Linoleic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMBS, CMTM8, and ARHGAP10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HMBS grouped by Linoleic acid metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HMBS →	-0.519	-1.092	.009	.002	3	5
LUNG_SCLC	CMTM8 →	-1.303	-1.375	.003	.004	3	4
LUNG_SCLC	ARHGAP10 →	+1.856	+1.082	.001	.001	3	4
LIVER	FSTL1 →	+6.077	+1.583	<.001	.002	3	4
LUNG_NSCLC_LUSC	LARS2 →	-0.671	-1.192	.005	.005	3	4
OESOPHAGUS	SLC16A2 →	+2.075	+0.635	.004	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HMBS by Linoleic acid metabolic process activity — SKIN

Explore this box plot interactively →