Linoleic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Linoleic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FADS2, FADS1, and ELOVL5, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Linoleic acid metabolic process activity versus FADS2 in URINARY_TRACT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FADS2 →	+3.524	+0.249	<.001	<.001	3	18
STOMACH	FADS1 →	+2.692	+0.179	<.001	<.001	3	17
STOMACH	ELOVL5 →	+3.702	+0.198	<.001	<.001	3	10
BREAST	P3H1 →	+1.676	+0.236	<.001	<.001	3	10
LIVER	GSTP1 →	+6.534	+0.211	<.001	.008	3	8
BREAST	C5orf15 →	+0.742	+0.166	.001	.008	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043651 vs FADS2 — URINARY_TRACT

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