Dicarboxylic acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Dicarboxylic acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBI3, BIN2, and P2RY8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid biosynthetic process activity versus EBI3 in UCEC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EBI3 →	+0.656	+0.150	.001	.005	3	6
OV	BIN2 →	+0.762	+0.134	.001	<.001	3	6
GBM	P2RY8 →	+0.549	+0.150	.003	.001	3	6
UCEC	LILRB1 →	+0.787	+0.138	<.001	<.001	3	6
UCEC	BTK →	+0.787	+0.141	<.001	<.001	3	6
GBM	ARRB2 →	+0.406	+0.138	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043650 vs EBI3 — UCEC

Explore this scatter interactively →