Dicarboxylic acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Dicarboxylic acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTFP1, GOT1, and HSPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dicarboxylic acid biosynthetic process activity versus MTFP1 in OVARY (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MTFP1 →	+1.019	+0.286	<.001	.001	3	6
STOMACH	GOT1 →	+1.187	+0.323	.008	.002	3	6
LARGE_INTESTINE	HSPD1 →	+0.660	+0.221	.004	<.001	3	6
LIVER	ANKRD40 →	+0.984	+0.214	<.001	.002	3	6
KIDNEY	NHEJ1 →	+0.411	+0.243	.006	.001	3	5
KIDNEY	KLHL23 →	+1.213	+0.227	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043650 vs MTFP1 — OVARY

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